What is the primary concern when using fresh whole blood for transfusion?

The primary concern when using fresh whole blood for transfusion is that it is not tested or approved for use within 24 hours. Fresh whole blood is often collected and can be used for transfusions in emergency situations where rapid resuscitation is necessary. However, this collected blood has not undergone standard testing protocols within that timeframe, which raises concerns about the safety and compatibility of the blood with the recipient.

Blood testing is crucial to identify and eliminate any risks like infectious diseases or other incompatibilities. Therefore, using fresh whole blood immediately without proper testing can pose significant risks to the patient, making monitoring and testing vital components of safe transfusion practices.

The other choices relate to considerations of storage, costs, and efficacy, but they do not encompass the immediate safety implications that arise from the lack of testing within the first 24 hours after collection.